Growth and nutritional management of children on peritoneal dialysis
Stunting and malnutrition are common in children with chronic kidney disease and increase with the degree of impairment to be maximal in children at the dialysis stage, leading to a risk of excess mortality. Despite many advances in the field of pediatric dialysis, small size in adulthood remains very common in this population. The origin of malnutrition and stunting is complex and multifactorial. In infants on peritoneal dialysis, insufficient nutritional intake is recognized as a major barrier to adequate growth. The diagnostic approach to undernutrition and stunting in peritoneal dialysis requires the use of several elements: an interrogation, a clinical examination, and various complementary examinations. Due to the multifactorial aspect of the nutritional and statural status of the child, several therapeutic axes are to be taken into account, namely a nutritional treatment adapted to the needs of the child, a treatment by growth hormone, and an optimization of dialysis to allow optimal metabolic control.
Picca M, Perfumo F, Verrina E, Lavoratti G, Rinaldi S, Rizzoni G, Zacchello G, Ciofani Chesnaye N, Bonthuis M, Schaefer F, Groothoff JW, Verrina E, Heaf JG, Jankauskiene A, Lukosiene V, Molchanova EA, Mota C, Peco-Antic A, Ratsch IM, Bjerre A, Roussinov DL, Sukalo A, Topaloglu R, Van Hoeck K, Zagozdzon I, Jager KJ, Van Stralen KJ, registry EE-E (2014) Demographics of paediatric renal replacement therapy in Europe: a report of the ESPN/ERA-EDTA registry. Pediatr Nephrol 29:2403-2410.
Wong CS, Gipson DS, Gillen DL, Emerson S, Koepsell T, Sherrard DJ, Watkins SL, Stehman-Breen C (2000) Anthropometric measures and risk of death in children with end-stage renal disease. Am J Kidney Dis 36:811-819.
Harambat J, Bonthuis M, Groothoff JW, Schaefer F, Tizard EJ, Verrina E, van Stralen KJ, Jager KJ (2016) Lessons learned from the ESPN/ERA-EDTA Registry. Pediatr Nephrol 31:2055-2064.
Ingulli EG, Mak RH (2014) Growth in children with chronic kidney disease: role of nutrition, growth hormone, dialysis, and steroids. Curr Opin Pediatr 26:187-192.
Nissel R, Brazda I, Feneberg R, Wigger M, Greiner C, Querfeld U, Haffner D (2004) Effect of renal transplantation in childhood on longitudinal growth and adult height. Kidney Int 66:792-800.
Rees L, Mak RH (2011) Nutrition and growth in children with chronic kidney disease. Nat Rev Nephrol 7:615-623.
Norman LJ, Coleman JE, Macdonald IA, Tomsett AM, Watson AR (2000) Nutrition and growth in relation to severity of renal disease in children. Pediatr Nephrol 15:259-265.
Seikaly MG, Salhab N, Warady BA, Stablein D (2007) Use of rhGH in children with chronic kidney disease: lessons from NAPRTCS. Pediatr Nephrol 22:1195-1204.
Fine RN, Martz K, Stablein D (2010) What have 20 years of data from the North American Pediatric Renal Transplant Cooperative Study taught us about growth following renal transplantation in infants, children, and adolescents with end-stage renal disease? Pediatr Nephrol 25:739-746.
Al-Uzri A, Matheson M, Gipson DS, Mendley SR, Hooper SR, Yadin O, Rozansky DJ, Moxey-Mims M, Furth SL, Warady BA, Gerson AC, Chronic Kidney Disease in Children Study G (2013) The impact of short stature on health-related quality of life in children with chronic kidney disease. J Pediatr 163:736-741 e731.
Judge TA, Cable DM (2004) The effect of physical height on workplace success and income: preliminary test of a theoretical model. J Appl Psychol 89:428-441.
Mak RH, Cheung WW, Roberts CT, Jr. (2008) The growth hormone-insulin-like growth factor-I axis in chronic kidney disease. Growth Horm IGF Res 18:17-25.
Franke D, Alakan H, Pavicic L, Gellermann J, Muller D, Querfeld U, Haffner D, Zivicnjak M (2013) Birth parameters and parental height predict growth outcome in children with chronic kidney disease. Pediatr Nephrol 28:2335-2341.
Greenbaum LA, Munoz A, Schneider MF, Kaskel FJ, Askenazi DJ, Jenkins R, Hotchkiss H, Moxey-Mims M, Furth SL, Warady BA (2011) The association between abnormal birth history and growth in children with CKD. Clin J Am Soc Nephrol 6:14-21.
Schaefer F, Benner L, Borzych-Duzalka D, Zaritsky J, Xu H, Rees L, Antonio ZL, Serdaroglu E, Hooman N, Patel H, Sever L, Vondrak K, Flynn J, Rebori A, Wong W, Holtta T, Yildirim ZY, Ranchin B, Grenda R, Testa S, Drozdz D, Szabo AJ, Eid L, Basu B, Vitkevic R, Wong C, Pottoore SJ, Muller D, Dusunsel R, Celedon CG, Fila M, Sartz L, Sander A, Warady BA, International Pediatric Peritoneal Dialysis Network R (2019) Global Variation of Nutritional Status in Children Undergoing Chronic Peritoneal Dialysis: A Longitudinal Study of the International Pediatric Peritoneal Dialysis Network. Sci Rep 9:4886.
de Camargo MF, Henriques CL, Vieira S, Komi S, Leao ER, Nogueira PC (2014) Growth of children with end-stage renal disease undergoing daily hemodialysis. Pediatr Nephrol 29:439-444.
Fischbach M, Terzic J, Menouer S, Dheu C, Seuge L, Zalosczic A (2010) Daily on line haemodiafiltration promotes catch-up growth in children on chronic dialysis. Nephrol Dial Transplant 25:867-873.
Mekahli D, Shaw V, Ledermann SE, Rees L (2010) Long-term outcome of infants with severe chronic kidney disease. Clin J Am Soc Nephrol 5:10-17.
Ledermann SE, Shaw V, Trompeter RS (1999) Long-term enteral nutrition in infants and young children with chronic renal failure. Pediatr Nephrol 13:870-875.
Holtta T, Ronnholm K, Jalanko H, Holmberg C (2000) Clinical outcome of pediatric patients on peritoneal dialysis under adequacy control. Pediatr Nephrol 14:889-897.
Paglialonga F, Edefonti A (2009) Nutrition assessment and management in children on peritoneal dialysis. Pediatr Nephrol 24:721-730.
Mak RH, Cheung W, Cone RD, Marks DL (2006) Leptin and inflammation-associated cachexia in chronic kidney disease. Kidney Int 69:794-797.
Armstrong JE, Laing DG, Wilkes FJ, Kainer G (2010) Smell and taste function in children with chronic kidney disease. Pediatr Nephrol 25:1497-1504.
Fouque D, Kalantar-Zadeh K, Kopple J, Cano N, Chauveau P, Cuppari L, Franch H, Guarnieri G, Ikizler TA, Kaysen G, Lindholm B, Massy Z, Mitch W, Pineda E, Stenvinkel P, Trevino-Becerra A, Wanner C (2008) A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease. Kidney Int 73:391-398.
Rajan VR, Mitch WE (2008) Muscle wasting in chronic kidney disease: the role of the ubiquitin proteasome system and its clinical impact. Pediatr Nephrol 23:527-535.
Workeneh BT, Mitch WE (2010) Review of muscle wasting associated with chronic kidney disease. Am J Clin Nutr 91:1128S-1132S.
Nourbakhsh N, Rhee CM, Kalantar-Zadeh K (2014) Protein-energy wasting and uremic failure to thrive in children with chronic kidney disease: they are not small adults. Pediatr Nephrol 29:2249-2252.
Mak RH, Cheung WW, Zhan JY, Shen Q, Foster BJ (2012) Cachexia and protein-energy wasting in children with chronic kidney disease. Pediatr Nephrol 27:173-181.
Abraham AG, Mak RH, Mitsnefes M, White C, Moxey-Mims M, Warady B, Furth SL (2014) Protein energy wasting in children with chronic kidney disease. Pediatr Nephrol 29:1231-1238.
Brem AS, Lambert C, Hill C, Kitsen J, Shemin DG (2002) Prevalence of protein malnutrition in children maintained on peritoneal dialysis. Pediatr Nephrol 17:527-530.
Edefonti A, Picca M, Damiani B, Garavaglia R, Loi S, Ardissino G, Marra G, Ghio L (2001) Prevalence of malnutrition assessed by bioimpedance analysis and anthropometry in children on peritoneal dialysis. Perit Dial Int 21:172-179.
Canepa A, Perfumo F, Carrea A, Menoni S, Trivelli A, Delucchi P, Gusmano R (1996) Nutritional status in children receiving chronic peritoneal dialysis. Perit Dial Int 16 Suppl 1:S526-531.
Edefonti A, Paglialonga F,A, Sorino P, Loi S, Grassi MR (2006) A prospective multicentre study of the nutritional status in children on chronic peritoneal dialysis. Nephrol Dial Transplant 21:1946-1951.
Bonthuis M, van Stralen KJ, Verrina E, Groothoff JW, Alonso Melgar A, Edefonti A, Fischbach M, Mendes P, Molchanova EA, Paripovic D, Peco-Antic A, Printza N, Rees L, Rubik J, Stefanidis CJ, Sinha MD, Zagozdzon I, Jager KJ, Schaefer F (2013) Underweight, overweight and obesity in paediatric dialysis and renal transplant patients. Nephrol Dial Transplant 28 Suppl 4:iv195-iv204.
Group KW (2009) KDOQI Clinical Practice Guideline for Nutrition in Children with CKD: 2008 update. Executive summary. Am J Kidney Dis 53:S11-104.
Kuczmarski RJ, Ogden CL, Grummer-Strawn LM, Flegal KM, Guo SS, Wei R, Mei Z, Curtin LR, Roche AF, Johnson CL (2000) CDC growth charts: United States. Adv Data:1-27.
Tanner JM, Whitehouse RH, Takaishi M (1966) Standards from birth to maturity for height, weight, height velocity, and weight velocity: British children, 1965. I. Arch Dis Child 41:454-471.
Tanner JM, Whitehouse RH, Takaishi M (1966) Standards from birth to maturity for height, weight, height velocity, and weight velocity: British children, 1965. II. Arch Dis Child 41:613-635.
Rolland-Cachera MF, Sempe M, Guilloud-Bataille M, Patois E, Pequignot-Guggenbuhl F, Fautrad V (1982) Adiposity indices in children. Am J Clin Nutr 36:178-184.
Frisancho AR (1981) New norms of upper limb fat and muscle areas for assessment of nutritional status. Am J Clin Nutr 34:2540-2545.
Ulijaszek SJ, Kerr DA (1999) Anthropometric measurement error and the assessment of nutritional status. Br J Nutr 82:165-177.
Wong CS, Hingorani S, Gillen DL, Sherrard DJ, Watkins SL, Brandt JR, Ball A, Stehman-Breen CO (2002) Hypoalbuminemia and risk of death in pediatric patients with end-stage renal disease. Kidney Int 61:630-637.
Borah MF, Schoenfeld PY, Gotch FA, Sargent JA, Wolfsen M, Humphreys MH (1978) Nitrogen balance during intermittent dialysis therapy of uremia. Kidney Int 14:491-500.
Mendley SR, Majkowski NL (2000) Urea and nitrogen excretion in pediatric peritoneal dialysis patients. Kidney Int 58:2564-2570.
(2000) Clinical practice guidelines for nutrition in chronic renal failure. K/DOQI, National Kidney Foundation. Am J Kidney Dis 35:S1-140.
Polite AL, Jr., Cottrell JC, Lowry B, Reisman L (1975) Letter: Drug-induced morphological changes in white blood cells. Am J Med Technol 41:130-131.
Edefonti A, Picca M, Damiani B, Loi S, Consalvo G, Giani M, Ghio L, Origgi G, Ferrario M (2000) Models to assess nitrogen losses in pediatric patients on chronic peritoneal dialysis. Pediatr Nephrol 15:25-30.
Mastrangelo A, Paglialonga F, Edefonti A (2014) Assessment of nutritional status in children with chronic kidney disease and on dialysis. Pediatr Nephrol 29:1349-1358.
Schaefer F, Georgi M, Zieger A, Scharer K (1994) Usefulness of bioelectric impedance and skinfold measurements in predicting fat-free mass derived from total body potassium in children. Pediatr Res 35:617-624.
Rees L (2015) 3.21 Nutritional management in children with chronic kidney disease. World Rev Nutr Diet 113:254-258.
Nelms CL (2018) Optimizing Enteral Nutrition for Growth in Pediatric Chronic Kidney Disease (CKD). Front Pediatr 6:214.
Watson AR, Coleman JE, Warady BA (1998) hen and How to Use Nasogastric and Gastrostomy Feeding for Nutritional Support in Infants and Children on CAPD/CCPD. In: Springer Boston M (ed) Fine RN, Alexander SR, Warady BA (eds) CAPD/CCPD in Children.
Prestidge C, Ronaldson J, Wong W, Stack M, Kara T (2015) Infectious outcomes following gastrostomy in children receiving peritoneal dialysis. Pediatr Nephrol 30:849-854.
Ramage IJ, Geary DF, Harvey E, Secker DJ, Balfe JA, Balfe JW (1999) Efficacy of gastrostomy feeding in infants and older children receiving chronic peritoneal dialysis. Perit Dial Int 19:231-236.
Rees L, Azocar M, Borzych D, Watson AR, Buscher A, Edefonti A, Bilge I, Askenazi D, Leozappa G, Gonzales C, van Hoeck K, Secker D, Zurowska A, Ronnholm K, Bouts AH, Stewart H, Ariceta G, Ranchin B, Warady BA, Schaefer F, International Pediatric Peritoneal Dialysis Network r (2011) Growth in very young children undergoing chronic peritoneal dialysis. J Am Soc Nephrol 22:2303-2312.
Rees L, Jones H (2013) Nutritional management and growth in children with chronic kidney disease. Pediatr Nephrol 28:527-536.
Ellis EN, Yiu V, Harley F, Donaldson LA, Hand M, Warady BA, Wood EG, North American Pediatric Renal Transplant Cooperative S (2001) The impact of supplemental feeding in young children on dialysis: a report of the North American Pediatric Renal Transplant Cooperative Study. Pediatr Nephrol 16:404-408.
Canepa A, Verrina E, Perfumo F, Carrea A, Menoni S, Delucchi P, Gusmano R (1999) Value of intraperitoneal amino acids in children treated with chronic peritoneal dialysis. Perit Dial Int 19 Suppl 2:S435-440.
Canepa A, Perfumo F, Carrea A, Giallongo F, Verrina E, Cantaluppi A, Gusmano R (1991) Long-term effect of amino-acid dialysis solution in children on continuous ambulatory peritoneal dialysis. Pediatr Nephrol 5:215-219.
Hanning RM, Balfe JW, Zlotkin SH (1987) Effectiveness and nutritional consequences of amino acid-based vs glucose-based dialysis solutions in infants and children receiving CAPD. Am J Clin Nutr 46:22-30.
Li FK, Chan LY, Woo JC, Ho SK, Lo WK, Lai KN, Chan TM (2003) A 3-year, prospective, randomized, controlled study on amino acid dialysate in patients on CAPD. Am J Kidney Dis 42:173-183.
van Huis M, Bonthuis M, Sahpazova E, Mencarelli F, Spasojevic B, Reusz G, Caldas-Afonso A, Bjerre A, Baiko S, Vondrak K, Molchanova EA, Kolvek G, Zaikova N, Bohm M, Ariceta G, Jager KJ, Schaefer F, van Stralen KJ, Groothoff JW (2016) Considerable variations in growth hormone policy and prescription in paediatric end-stage renal disease across European countries-a report from the ESPN/ERA-EDTA registry. Nephrol Dial Transplant 31:609-619.
Fine RN (1991) Growth hormone and the kidney: the use of recombinant human growth hormone (rhGH) in growth-retarded children with chronic renal insufficiency. J Am Soc Nephrol 1:1136-1145.
Gupta V, Lee M (2012) Growth hormone in chronic renal disease. Indian J Endocrinol Metab 16:195-203.
Mehls O, Wuhl E, Haffner D, Schaefer F, Tonshoff B (1996) Growth hormone treatment of short children with chronic renal failure before and after renal transplantation: rationale and recent results. Nephrol Dial Transplant 11:1747-1750.
Laakkonen H, Happonen JM, Marttinen E, Paganus A, Holtta T, Holmberg C, Ronnholm K (2010) Normal growth and intravascular volume status with good metabolic control during peritoneal dialysis in infancy. Pediatr Nephrol 25:1529-1538.
Schaefer F, Klaus G, Mehls O (1999) Peritoneal transport properties and dialysis dose affect growth and nutritional status in children on chronic peritoneal dialysis. Mid-European Pediatric Peritoneal Dialysis Study Group. J Am Soc Nephrol 10:1786-1792.
Stanczyk M, Miklaszewska M, Zachwieja K, Wiercinski R, Stankiewicz R, Firszt-Adamczyk A, Zachwieja J, Borzecka H, Zagozdzon I, Ziolkowska H, Leszczynska B, Medynska A, Adamczyk P, Szczepanska M, Tkaczyk M (2016) Growth and nutritional status in children with chronic kidney disease on maintenance dialysis in Poland. Adv Med Sci 61:46-51.
Schmitt CP, Zaloszyc A, Schaefer B, Fischbach M (2011) Peritoneal dialysis tailored to pediatric needs. Int J Nephrol 2011:940267.
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